A MONOALLELIC DELETION OF THE TCCRT GENE INCREASES THE ATTENUATION OF A CULTURED TRYPANOSOMA CRUZI STRAIN, PROTECTING AGAINST AN IN VIVO VIRULENT CHALLENGE.

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity.In a previous work, we characterized a clonal cell line lacking one TcCRT allele (TcCRT+/-) and another overexpressing it (

This article analyses the reasons for the emergence of a new phenomenon of remunerated crowdfunding, the risks involved, and their management before the emergence of European crowd funding service providers for business regulation in EU (Crowdfunding Regulation).In accepting deposits and granting loans, the activities of loan-based crowdfunding are

Background: Androgenic anabolic steroids (AASs) have a number of licensed clinical indications but are also subject to abuse within the body building community.They have a number of potentially important adverse pharmacological effects, and users require health monitoring, including selected laboratory investigations.The extent to which AAS users a

Pilgrimages played a major role in the life of people from various cultural circles including Polish and German territories, whose inhabitants took part in peregrinations maiores, pilgrimages to Rome, Jerusalem, Santa Sacks Santiago de Compostela or other geographically remote places.Local sanctuaries developed rapidly in the territories discussed